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Macrophages and epithelial cells respond differently to the Pseudomonas aeruginosa type III secretion system. Infect Immun 1999 Jun;67(6):3151-4

Date

05/25/1999

Pubmed ID

10338535

Pubmed Central ID

PMC96636

Scopus ID

2-s2.0-0033031869   58 Citations

Abstract

The multiple effects of Pseudomonas aeruginosa type III secretion have largely been attributed to variations in cytotoxin expression between strains. Here we show that the target cell type is also important. While lung epithelial cells showed significant changes in morphology but not viability when infected with P. aeruginosa, macrophages were efficiently killed by P. aeruginosa. Both responses were dependent on the type III secretion system.

Author List

Coburn J, Frank DW

Authors

Jenifer Coburn PhD Professor in the Medicine department at Medical College of Wisconsin
Dara W. Frank PhD Professor in the Microbiology and Immunology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

3T3 Cells
ADP Ribose Transferases
Animals
Epithelial Cells
Humans
Macrophages
Mice
Mice, Inbred A
Pseudomonas aeruginosa
Tumor Cells, Cultured
jenkins-FCD Prod-409 d1e206b0be345926047b0d9c353c78a4cce4058b