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Macrophages and epithelial cells respond differently to the Pseudomonas aeruginosa type III secretion system. Infect Immun 1999 Jun;67(6):3151-4 PMID: 10338535 PMCID: PMC96636

Pubmed ID



The multiple effects of Pseudomonas aeruginosa type III secretion have largely been attributed to variations in cytotoxin expression between strains. Here we show that the target cell type is also important. While lung epithelial cells showed significant changes in morphology but not viability when infected with P. aeruginosa, macrophages were efficiently killed by P. aeruginosa. Both responses were dependent on the type III secretion system.

Author List

Coburn J, Frank DW


Jenifer Coburn PhD Professor in the Medicine department at Medical College of Wisconsin
Dara W. Frank PhD Professor in the Microbiology and Immunology department at Medical College of Wisconsin


2-s2.0-0033031869   57 Citations

MESH terms used to index this publication - Major topics in bold

3T3 Cells
ADP Ribose Transferases
Epithelial Cells
Mice, Inbred A
Pseudomonas aeruginosa
Tumor Cells, Cultured
jenkins-FCD Prod-321 98992d628744e349846c2f62ac68f241d7e1ea70