Robust indices of Hardy-Weinberg disequilibrium for QTL fine mapping. Hum Hered 2003;56(4):160-5
Date
03/20/2004Pubmed ID
15031618DOI
10.1159/000076391Scopus ID
2-s2.0-1642635110 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Hardy-Weinberg disequilibrium (HWD) measures have been proposed using dense markers to fine map a quantitative trait locus (QTL) to regions < approximately 1 cM. Earlier HWD measures may introduce bias in the fine mapping because they are dependent on marker allele frequencies across loci. Hence, HWD indices that do not depend on marker allele frequencies are desired for fine mapping. Based on our earlier work, here we present four new HWD indices that do not depend on marker allele frequencies. Two are for use when marker allele frequencies in a study population are known, and two are for use when marker allele frequencies in a study population are not known and are only known in the extreme samples. The new measures are a function of the genetic distance between the marker locus and a QTL. Through simulations, we investigated and compared the fine mapping performance of the new HWD measures with that of the earlier ones. Our results show that when marker allele frequencies vary across loci, the new measures presented here are more robust and powerful.
Author List
Deng HW, Li YM, Li MX, Liu PYMESH terms used to index this publication - Major topics in bold
Chromosome MappingComputer Simulation
Genetic Markers
Humans
Linkage Disequilibrium
Quantitative Trait Loci