Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learn Mem 2011 Jan;18(1):15-8 PMID: 21164173 PMCID: PMC3023966


Producing and maintaining distinct (orthogonal) neural representations for similar events is critical to avoiding interference in long-term memory. Recently, our laboratory provided the first evidence for separation-like signals in the human CA3/dentate. Here, we extended this by parametrically varying the change in input (similarity) while monitoring CA1 and CA3/dentate for separation and completion-like signals using high-resolution fMRI. In the CA1, activity varied in a graded fashion in response to increases in the change in input. In contrast, the CA3/dentate showed a stepwise transfer function that was highly sensitive to small changes in input.

Author List

Lacy JW, Yassa MA, Stark SM, Muftuler LT, Stark CE


Lutfi Tugan Muftuler PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Analysis of Variance
Brain Mapping
CA1 Region, Hippocampal
CA3 Region, Hippocampal
Dentate Gyrus
Discrimination (Psychology)
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Pattern Recognition, Visual
Photic Stimulation
Reaction Time
Transfer (Psychology)

View this publication's entry at the Pubmed website PMID: 21164173
jenkins-FCD Prod-185 20a1a87aaef305b3f5a3e8bb55f731baa68cadd0