Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learn Mem 2011 Jan;18(1):15-8
Date
12/18/2010Pubmed ID
21164173Pubmed Central ID
PMC3023966DOI
10.1101/lm.1971111Scopus ID
2-s2.0-78650994901 (requires institutional sign-in at Scopus site) 265 CitationsAbstract
Producing and maintaining distinct (orthogonal) neural representations for similar events is critical to avoiding interference in long-term memory. Recently, our laboratory provided the first evidence for separation-like signals in the human CA3/dentate. Here, we extended this by parametrically varying the change in input (similarity) while monitoring CA1 and CA3/dentate for separation and completion-like signals using high-resolution fMRI. In the CA1, activity varied in a graded fashion in response to increases in the change in input. In contrast, the CA3/dentate showed a stepwise transfer function that was highly sensitive to small changes in input.
Author List
Lacy JW, Yassa MA, Stark SM, Muftuler LT, Stark CEAuthor
Lutfi Tugan Muftuler PhD Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Analysis of VarianceBrain Mapping
CA1 Region, Hippocampal
CA3 Region, Hippocampal
Dentate Gyrus
Hippocampus
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Memory
Oxygen
Pattern Recognition, Visual
Photic Stimulation
Reaction Time