Increased colonic ornithine decarboxylase activity in inflammatory bowel disease in children. Dig Dis Sci 1999 Aug;44(8):1565-70
Date
09/24/1999Pubmed ID
10492133DOI
10.1023/a:1026654725101Scopus ID
2-s2.0-0032857184 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
The risk of colorectal carcinoma is increased in pediatric-onset inflammatory bowel disease (IBD). There is little information available regarding the colonic mucosal proliferative state in children with IBD. The aim of this study was to assess colonic ornithine decarboxylase (ODC) activity, a marker of cell proliferation, in pediatric IBD patients. ODC activity was assessed in colonic mucosa from 23 children (7 with ulcerative colitis, 9 with Crohn's disease, and 7 controls) undergoing colonoscopic examination. ODC activities were then compared with degree of inflammation of biopsied samples. ODC activities in patients with and without corticosteroid treatment were also analyzed. The mucosal ODC activities of sigmoid colon and rectum were significantly higher (2.5- to 4-fold) in both ulcerative colitis and Crohn's disease. The higher ODC activity was associated with increased mucosal inflammation. Moreover, treatment with corticosteroids decreased the ODC activity. In conclusion, using ODC activities as a marker of cell proliferation, our results suggest that there is a higher colonic mucosal proliferative state in children with IBD. The increased ODC activities were associated with increased colonic mucosal inflammation. Colonic mucosal ODC activity may provide an additional parameter to access the therapeutic efficacy of corticosteroid treatment in pediatric IBD patients.
Author List
Pillai RB, Tolia V, Rabah R, Simpson PM, Vijesurier R, Lin CHAuthor
Pippa M. Simpson PhD Adjunct Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdrenal Cortex Hormones
Child
Child, Preschool
Colitis, Ulcerative
Colon
Crohn Disease
Female
Humans
Intestinal Mucosa
Male
Mitotic Index
Ornithine Decarboxylase
Prospective Studies
Reference Values
