Multifactorial basis for coronary collateralization: a complex adaptive response to ischemia. Cardiovasc Res 1999 Jul;43(1):44-57
Date
10/28/1999Pubmed ID
10536689DOI
10.1016/s0008-6363(99)00077-2Scopus ID
2-s2.0-0033001169 (requires institutional sign-in at Scopus site) 60 CitationsAbstract
Angiogenesis and vasculogenesis are adaptive responses of the coronary collateral circulation to myocardial ischemia. This review focuses on the concerted action of growth factors, growth factor receptors, extracellular matrix, and inflammatory cellular responses to regulate angiogenesis and vasculogenesis in response to myocardial ischemia and alterations in shear stress. Therapeutic angiogenesis represents a novel approach to increase myocardial perfusion in patients with coronary artery disease and provides an opportunity to further clarify the mechanisms that regulate collateral development. Impairment of angiogenic adaptive responses to ischemia during disease states is an important subject for future investigation.
Author List
Kersten JR, Pagel PS, Chilian WM, Warltier DCMESH terms used to index this publication - Major topics in bold
AnimalsCollateral Circulation
Coronary Circulation
Growth Substances
Humans
Myocardial Ischemia
Nitric Oxide
Rats
Receptors, Growth Factor
