Faculty Collaboration Database

Posttransplantation lymphoproliferative disease in children: otolaryngologic manifestations and management. South Med J 1999 Nov;92(11):1079-82

Date

12/10/1999

Pubmed ID

10586834

DOI

10.1097/00007611-199911000-00007

Scopus ID

2-s2.0-0032740103 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

BACKGROUND: Posttransplantation lymphoproliferative disease (PTLD) is associated with Epstein-Barr virus (EBV) infection after solid organ and bone marrow transplantation.

METHODS: We did a retrospective analysis of cases with a diagnosis of PTLD at Children's Hospital of Wisconsin.

RESULTS: Ten patients were identified. Seven of 10 cases (70%) were associated with bone marrow transplantation and 3 with solid organ transplantation. Three patients (30%) died of PTLD. The average time to development of PTLD after transplantation was 120 days.

CONCLUSIONS: Otolaryngologic symptoms and findings are often the first manifestations of PTLD. Associated findings in this series included tonsillar necrosis, tonsillitis, airway obstruction, lymphadenitis, sinusitis, and otitis media. Diagnosis generally requires pathologic evaluation of tonsillar or adenoid tissue. Surgical intervention may also be important for relief of airway obstruction when present. Prompt recognition, diagnosis, and intervention with reduction in immunosuppression and antiviral therapy are essential to reduce the mortality of PTLD.

Author List

Posey LA, Kerschner JE, Conley SF

Author

Joseph E. Kerschner MD Provost, Executive Vice President, Dean, Professor in the School of Medicine Administration department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Airway Obstruction
Bone Marrow Transplantation
Child
Deglutition Disorders
Epstein-Barr Virus Infections
Heart Transplantation
Humans
Liver Transplantation
Lymphoproliferative Disorders
Otorhinolaryngologic Diseases
Retrospective Studies
Syndrome