Faculty Collaboration Database

Allelic distribution of the glycoprotein Ia (alpha2-integrin) C807T/G873A dimorphisms among caucasian venous thrombosis patients and six racial groups. Br J Haematol 1999 Dec;107(3):563-5

Date

12/03/1999

Pubmed ID

10583259

DOI

10.1046/j.1365-2141.1999.01753.x

Scopus ID

2-s2.0-0032755030 (requires institutional sign-in at Scopus site)   25 Citations

Abstract

Two linked silent dimorphisms, 807 C --> T (Phe224) and 873 G --> A (Thr246) within the glycoprotein Ia (GPIa) gene have been correlated with low and high platelet receptor density, respectively, and associated with vascular disease. A multiplexed allele-specific PCR assay was used to determine the GPIa 807T/873A allele frequency among 331 Caucasian venous thrombosis patients and 3571 unrelated individuals belonging to six different racial groups. The 807T/873A allele frequencies were 54%, 51%, 39%, 39%, 38%, 34% and 30% among Native Americans, Hispanics, Caucasians, Caucasian venous thrombosis patients, Asian Indians, African-Americans, and Koreans, respectively. Significant differences in the GPIa allele frequency among racial groups were revealed which emphasized the need for appropriate controls in studies evaluating the association of GPIa genotype to vascular disease.

Author List

Dinauer DM, Friedman KD, Hessner MJ

Authors

Kenneth D. Friedman MD Professor in the Medicine department at Medical College of Wisconsin
Martin J. Hessner PhD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Alleles
Antigens, CD
Gene Frequency
Genotype
Humans
Integrin alpha2
Polymerase Chain Reaction
Venous Thrombosis