Faculty Collaboration Database

High-salt diet and hypertension: focus on the renin-angiotensin system. Kidney Blood Press Res 2011;34(1):1-11

Date

11/13/2010

Pubmed ID

21071956

Pubmed Central ID

PMC3214830

DOI

10.1159/000320387

Scopus ID

2-s2.0-78149355625 (requires institutional sign-in at Scopus site)   129 Citations

Abstract

A high-salt diet is one of the major risk factors in the development and maintenance of hypertension. Numerous experimental and observational studies have confirmed the association of sodium intake with blood pressure levels. The effects of a high-salt diet are related to the function of the renin-angiotensin system, which is normally suppressed by a high-salt diet. Endothelial dysfunction probably plays an important role in the influence of high sodium intake on blood pressure, although the exact mechanisms remain elusive. Genetic factors are known to be very important, and various consomic and congenic rat strains as animal models have proven to be very useful in bringing us a step closer to understanding the interaction between salt intake and hypertension. In this article, experimental data obtained in studies on animals and humans, as well as epidemiological data are reviewed.

Author List

Drenjančević-Perić I, Jelaković B, Lombard JH, Kunert MP, Kibel A, Gros M

MESH terms used to index this publication - Major topics in bold

Animals
Blood Pressure
Diet, Sodium-Restricted
Humans
Hypertension
Renin-Angiotensin System
Risk Factors
Sodium, Dietary