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Microvascular flow and tissue PO(2) in skeletal muscle of chronic reduced renal mass hypertensive rats. Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2295-302 PMID: 11045965


This study determined whether arteriolar blood flow, capillary red blood cell (RBC) velocity, capillary hematocrit (Hct(cap)), and tissue PO(2) are altered in cremaster muscles of rats with chronic reduced renal mass hypertension (RRM-HT) relative to normotensive rats on high- or low-salt (NT-HS vs. NT-LS) diet. The blood flow in first- through third-order arterioles was not different between NT and HT rats, either at rest or during maximal relaxation of the vessels with 10(-4) M adenosine. Capillary RBC velocity was similar between the groups at rest but was elevated in RRM-HT and NT-HS rats during adenosine superfusion. Hct(cap) was reduced at rest in RRM-HT and NT-HS rats compared with NT-LS and was reduced in RRM-HT rats during adenosine-induced dilation. Tissue PO(2) was reduced in RRM-HT and NT-HS rats compared with NT-LS rats during control conditions and was lower in RRM-HT than in NT-LS rats during adenosine-induced dilation. These results indicate that both RRM-HT and chronic exposure of normotensive rats to a high-salt diet lead to reduced tissue oxygenation, despite the maintenance of normal arteriolar blood flow.

Author List

Lombard JH, Frisbee JC, Greene AS, Hudetz AG, Roman RJ, Tonellato PJ


Andrew S. Greene PhD Interim Vice Chair, Chief, Professor in the Biomedical Engineering department at Medical College of Wisconsin
Julian H. Lombard PhD Professor in the Physiology department at Medical College of Wisconsin
Peter J. Tonellato PhD Visiting Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Blood Flow Velocity
Blood Pressure
Chronic Disease
Hypertension, Renal
Muscle, Skeletal
Oxygen Consumption
Rats, Sprague-Dawley
Sodium Chloride, Dietary
Vascular Patency

View this publication's entry at the Pubmed website PMID: 11045965
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