Reactions of *NO, *NO2 and peroxynitrite in membranes: physiological implications. Free Radic Res 1999 Dec;31(6):597-606
Date
01/12/2000Pubmed ID
10630683DOI
10.1080/10715769900301171Scopus ID
2-s2.0-0032585706 (requires institutional sign-in at Scopus site) 55 CitationsAbstract
Nitric oxide (*NO) and nitrogen dioxide (*NO2) are hydrophobic gases. Therefore, lipid membranes and hydrophobic regions of proteins are potential sinks for these species. In these hydrophobic environments, reactive nitrogen species will exhibit different chemistry than in aqueous environments due to higher local concentrations and the lack of hydrolysis reactions. The peroxynitrite anion (ONOO-) and peroxynitrous acid (ONOOH) can freely pass through lipid membranes, making peroxynitrite-mediated reactions in a hydrophobic environment also of extreme relevance. The reactions observed by these reactive nitrogen species in a hydrophobic milieu include oxidation, nitration and even potent chain-breaking antioxidant reactions. The physiological and toxicological relevance of these reactions is discussed.
Author List
Goss SP, Singh RJ, Hogg N, Kalyanaraman BAuthors
Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of WisconsinBalaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsCell Membrane
Free Radicals
Humans
Lipoproteins, LDL
Metals
Nitrates
Nitric Oxide
Nitrogen Dioxide
Oxidation-Reduction
