Effects of a localized high-flow anastomosis between the aorta and left lower lobe pulmonary artery on great vessel flow and pulmonary arterial reactivity in the contralateral lung. J Thorac Cardiovasc Surg 2011 Feb;141(2):407-12
Date
11/16/2010Pubmed ID
21075384Pubmed Central ID
PMC3022966DOI
10.1016/j.jtcvs.2010.06.020Scopus ID
2-s2.0-78751591713 (requires institutional sign-in at Scopus site) 1 CitationAbstract
OBJECTIVES: We sought to assess the effects of a localized anastomosis between the aorta and left lower lobe pulmonary artery on flows through central vessels and on the vascular reactivity of small pulmonary arteries distal or contralateral to the shunt.
METHODS: Flow rates in major vessels and tensions from small pulmonary arteries from the left and right lower lobes were determined 48 hours after creation of an end-to-side anastomosis of the left lower lobe pulmonary artery to the aorta.
RESULTS: Anastomoses increased flow through the left lower lobe pulmonary artery from 194±6 to 452±18 mL/min immediately after anastomosis to 756±19 mL/min by the time of harvest (n=88, P<.05). Flow rates in main pulmonary arteries from hosts with anastomoses were lower (557±26 vs 1033±244 mL/min), whereas aortic root flows were not different from control values (1370±53 vs 1120±111 mL/min; P=.07). Wet/dry weights of both lungs and aortic flow rates were proportional to shunt flow rates. Pulmonary artery rings harvested from the right (unshunted) lobes of high-flow hosts exhibited increased reactivity to the thromboxane agonist U46619 and phenylephrine relative to those of left pulmonary arteries from the same animal or those of control hosts.
CONCLUSIONS: Our studies are the first to identify enhanced reactivity of pulmonary arteries in a lung contralateral to a localized high-output shunt between an aorta and pulmonary artery. These observations suggest that patients with localized systemic-to-pulmonary shunt could exhibit modified vascular tone in remote pulmonary arteries.
Author List
Somberg L, Nirula R, Bousamra M 2nd, Friesema J, Zhu D, Medhora M, Jacobs ERMESH terms used to index this publication - Major topics in bold
Anastomosis, SurgicalAnimals
Animals, Newborn
Aorta
Blood Flow Velocity
Dose-Response Relationship, Drug
Female
Lung
Male
Pulmonary Artery
Pulmonary Circulation
Regional Blood Flow
Swine
Time Factors
Vasoconstriction
Vasoconstrictor Agents
