Cellular immune response to viral peptides in patients exposed to HIV. AIDS Res Hum Retroviruses 1988 Aug;4(4):259-67
Date
08/01/1988Pubmed ID
2462895DOI
10.1089/aid.1988.4.259Scopus ID
2-s2.0-0023762615 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
In efforts to identify B cell and T cell epitopes of HIV-1 structural components, serum as well as lymphocytes from HIV-1-seropositive individuals were reacted with several recombinant and native peptides representing defined viral gag and env determinants. Several areas of discordance between humoral and cellular reactivity were identified. Specifically, the principal neutralizing site within HIV-1, the major envelope glycoprotein gp120, failed to elicit detectable cellular reactivities. The carboxyl portion of gp120 and the transmembrane gp41 region were uniformly recognized by patient antibodies but did not produce significant lymphocyte blastogenesis. However, the amino half of gp120 elicited cellular responses in a majority of the immunocompetent individuals tested, despite its extremely low reactivity with patient sera. Last, the major HIV-1 structure component p24 was found to be the most consistent T cell activation antigen among the panel tested.
Author List
Ahearne PM, Matthews TJ, Lyerly HK, White GC, Bolognesi DP, Weinhold KJAuthor
Gilbert C. White MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acquired Immunodeficiency SyndromeB-Lymphocytes
Enzyme-Linked Immunosorbent Assay
Epitopes
Gene Products, gag
HIV Antigens
HIV Seropositivity
HIV-1
Humans
Immunity, Cellular
Reference Values
Retroviridae Proteins
T-Lymphocytes
Viral Envelope Proteins