Prolonged neonatal alloimmune thrombocytopenic purpura associated with anti-Bak(a). Two cases in siblings. Am J Perinatol 1987 Jan;4(1):55-8
Date
01/01/1987Pubmed ID
3790217DOI
10.1055/s-2007-999737Scopus ID
2-s2.0-0023125406 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
Two cases of prolonged neonatal alloimmune thrombocytopenic purpura in siblings due to anti-Bak(a) are reported. The first case was complicated by an intracranial hemorrhage due to severe thrombocytopenia, but the second case had no untoward complications. Delivery by cesarean section and immediate platelet support from "compatible" (nonmaternal) donors may have contributed to the more favorable outcome in the second case. An analysis of the gene frequencies of platelet-specific antigens suggests that factors other than the potential for maternal exposure to antigen determine the incidence of affected births. Knowledge of gene frequencies may, however, permit a priori prenatal calculation of the probability of an affected birth for couples with a previously affected child even if the genotype of the father is unknown.
Author List
Miller DT, Etzel RA, McFarland JG, Aster RH, White GC 2ndAuthor
Gilbert C. White MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acute DiseaseAdult
Antigens, Human Platelet
Blood Platelets
Cerebral Hemorrhage
Female
Genotype
Humans
Infant, Newborn
Isoantibodies
Isoantigens
Male
Platelet Transfusion
Purpura, Thrombocytopenic
Time Factors