Medical College of Wisconsin
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Identification of Bakb, a new platelet-specific antigen associated with posttransfusion purpura. Blood 1988 Apr;71(4):894-8 PMID: 3355896

Pubmed ID

3355896

Abstract

Baka is a platelet alloantigen whose putative allele, Bakb, has not been identified previously. By using a serum, "Har," obtained from a patient with posttransfusion purpura, we describe the platelet alloantigen Bakb. The Har serum reacted with an NP-40-extractable platelet membrane protein of 142 kd with mobility similar to platelet glycoprotein IIb alpha. We found that the antigen recognized by the Har serum is inherited in an autosomal dominant mode with an apparent gene frequency of .39. Chi-square analysis of observed and expected phenotype frequencies indicated that serum Har recognizes Bakb, the anticipated allele of Baka. Our findings provide new evidence for polymorphism of glycoprotein IIb and for the association of posttransfusion purpura with alloimmunization to determinants on this glycoprotein.

Author List

Kickler TS, Herman JH, Furihata K, Kunicki TJ, Aster RH

Author

Richard H. Aster MD Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-0023818397   49 Citations

MESH terms used to index this publication - Major topics in bold

Antigens, Human Platelet
Blood Platelets
Electrophoresis, Agar Gel
Electrophoresis, Polyacrylamide Gel
Female
Gene Frequency
Humans
Immunoassay
Isoantibodies
Isoantigens
Middle Aged
Phenotype
Purpura, Thrombocytopenic
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e