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Designing equivalent treatment regimens for prostate radiotherapy based on equivalent uniform dose. Br J Radiol 2008 Jan;81(961):59-68 PMID: 18039721

Pubmed ID

18039721

Abstract

The purpose of this work was to determine alternative radiotherapy (RT) regimens that are biologically equivalent to clinically proven treatments using different RT modalities or different fractionation schemes. The concept of equivalent uniform dose (EUD) is used with the linear quadratic model to determine equivalent treatment regimens using two representative sets of parameters derived from clinical data: (i) alpha/beta = 3.1 Gy and alpha = 0.15 Gy(-1), and (ii) alpha/beta = 1.5 Gy and alpha = 0.04 Gy(-1). The EUD values for the critical structure (rectum) are also calculated. Representative dose volume histograms were used to account for dose inhomogeneities for different RT modalities. A series of alternative and equivalent fractionation regimens that can be used with different radiotherapy modalities for localized prostate cancer were determined. For example, the alternative regimens, calculated with the alpha/beta ratio of 3.1 Gy, that would be biologically equivalent to external beam RT (EBRT) of 76 Gy (38x2.0 Gy) include: EBRT hypofractionation of 21x3.0 Gy; I-125 implant of 156 Gy; Pd-103 implant of 128 Gy; high dose rate (HDR) brachytherapy of 4x10.5 Gy; I-125 implant of 65 Gy combined with EBRT of 23x2.0 Gy; and HDR brachytherapy of 3x5.9 Gy combined with EBRT of 23x2.0 Gy. Similar data for other parameters are also presented. With caution, the data presented may be useful in designing clinical trials to explore new RT strategies, such as image-guided intensity-modulated RT.

Author List

Li XA, Wang JZ, Stewart RD, Dibiase SJ, Wang D, Lawton CA

Authors

Colleen A. Lawton MD Vice Chair, Professor in the Radiation Oncology department at Medical College of Wisconsin
X Allen Li PhD Professor in the Radiation Oncology department at Medical College of Wisconsin




Scopus

2-s2.0-38449113806   9 Citations

MESH terms used to index this publication - Major topics in bold

Brachytherapy
Humans
Male
Models, Biological
Prostatic Neoplasms
Radiation Dosage
Radiotherapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Rectum
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e