Medical College of Wisconsin
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Regulation of expression of the Borrelia burgdorferi beta(3)-chain integrin ligand, P66, in ticks and in culture. Infect Immun 2003 Feb;71(2):1001-7 PMID: 12540584 PMCID: PMC145366

Pubmed ID

12540584

Abstract

Borrelia burgdorferi is maintained in an infection cycle between mammalian and arthropod hosts. Appropriate gene expression by B. burgdorferi at different stages of this cycle is probably essential for transmission and establishment of infection. The B. burgdorferi beta(3) integrin ligand P66 is expressed by the bacteria in mammals, laboratory culture, and engorged but not unfed ticks. No in vitro culture conditions in which P66 expression reflected that in the unfed tick were found, suggesting that there are aspects of B. burgdorferi-tick interaction that remain unexplored.

Author List

Cugini C, Medrano M, Schwan TG, Coburn J

Author

Jenifer Coburn PhD Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-0037306601   33 Citations

MESH terms used to index this publication - Major topics in bold

Animals
Bacterial Proteins
Borrelia burgdorferi
Culture Media
Feeding Behavior
Gene Expression Regulation, Bacterial
Hydrogen-Ion Concentration
Integrin beta3
Ixodes
Ligands
Mice
Porins
Temperature
jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6