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The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat. Neurosci Lett 2002 Dec 25;335(2):95-8 PMID: 12459507

Abstract

Several recent studies have demonstrated a neuromodulatory role for endocannabinoids via their ability to act as retrograde inhibitors of synaptic neurotransmission. We utilized the functional hyperemic response to controlled whisker stimulation to determine whether endogenous cannabinoids modulate synaptic transmission within the primary somatosensory cortex of rats. As previously demonstrated, whisker-stimulation resulted in a robust hyperemic response measured using laser Doppler flowmetry within the whisker barrel cortex. Administration of the CB(1) receptor antagonist, SR141716 (1 mg/kg i.v.), significantly potentiated the functional hyperemic response to whisker-stimulation, while having no effect on basal blood flow within the whisker barrel cortex. These data suggest that suppression of endogenous cannabinergic neurotransmission results in increased cortical activity in response to physiological sensory stimulation.

Author List

Patel S, Gerrits R, Muthian S, Greene AS, Hillard CJ

Authors

Ron Gerrits BS,PhD Faculty in the Biomedical Engineering department at Milwaukee School of Engineering
Andrew S. Greene PhD Interim Vice Chair, Chief, Professor in the Biomedical Engineering department at Medical College of Wisconsin
Cecilia J. Hillard PhD Associate Dean, Center Director, Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Endocannabinoids
Male
Piperidines
Pyrazoles
Rats
Rats, Sprague-Dawley
Reaction Time
Receptors, Cannabinoid
Receptors, Drug
Somatosensory Cortex
Synaptic Transmission
Vibrissae



View this publication's entry at the Pubmed website PMID: 12459507
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