Faculty Collaboration Database

Segment-specific c-ErbB2 expression in human autosomal recessive polycystic kidney disease. J Am Soc Nephrol 2001 Feb;12(2):379-384

Date

02/07/2001

Pubmed ID

11158230

DOI

10.1681/ASN.V122379

Scopus ID

2-s2.0-0035145952 (requires institutional sign-in at Scopus site)   28 Citations

Abstract

c-ErbB2 (also referred to as Neu or HER2), a transmembrane glycoprotein with intrinsic tyrosine kinase activity, is structurally related to epidermal growth factor receptor (EGFR) and forms active heterodimers with EGFR as well as other members of the EGFR family. c-ErbB2 is reported to mediate differentiation and proliferation in epithelial cells and is expressed in a tissue-specific and developmental stage-specific manner. Given the role of EGFR in cystic renal epithelial hyperplasia and the immature phenotype of cystic renal epithelial cells, the segment-specific expression pattern of c-ErbB2 in human autosomal recessive polycystic kidney disease (ARPKD) was examined in nine ARPKD kidney specimens ranging from gestational age 17 wk through postnatal age 4 wk. c-ErbB2 staining of human ARPKD samples showed increased expression with increasing gestational age compared with normal human fetal and postnatal kidneys. This increased c-ErbB2 expression was primarily localized to the apical surfaces of cystic collecting tubule cells, similar to the pattern of EGFR expression, and paralleled collecting tubular cyst formation and growth.

Author List

Nakanishi K, Sweeney WE Jr, Avner ED

Author

Ellis D. Avner MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

ErbB Receptors
Female
Humans
Immunohistochemistry
Kidney
Kidney Tubules, Collecting
Kidney Tubules, Proximal
Polycystic Kidney, Autosomal Recessive
Pregnancy
Receptor, ErbB-2