Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. Oncogene 2005 Mar 10;24(11):1958-63
Date
02/03/2005Pubmed ID
15688036DOI
10.1038/sj.onc.1208295Scopus ID
2-s2.0-16244410135 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
Pas1 candidate 1 (Pas1c1) gene (also named Lmna-rs1) was found to encode two alternatively spliced mRNA transcripts (i.e. Pas1c1-Va and Pas1c1-Vb). In this study, we identified three additional mRNA transcripts encoded by the Pas1c1 gene, which were designated as Pas1c1-Vc, Pas1c1-Vd, and Pas1c1-Ve, respectively. Similar to Pas1c1-Vb, the newly identified transcripts were only expressed in mouse lung tissues from strains carrying the Pas1-susceptible (Pas1/s) allele. Pas1c1 transcripts were also detected in heart, testis, or brain but not in liver, spleen, or kidney. An 11-nucleotide polymorphism was found within the 3'-acceptor splice site of exon 8, which cosegregates with mouse strain Pas1 alleles and may underlie the strain-specific exon 8 skipping. We also found that ectopic expression of the Pas1c1-Va and Pas1c1-Vb in COS7 and NIH3T3 cells exhibited distinct intracellular distributions. These results support that Pas1c1 as a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation.
Author List
Wang M, Futamura M, Wang Y, You MMESH terms used to index this publication - Major topics in bold
AdenomaAmino Acid Sequence
Animals
Base Sequence
DNA Primers
Exons
Genetic Predisposition to Disease
Lung Neoplasms
Mice
Molecular Sequence Data
Sequence Alignment
Sequence Homology, Amino Acid
Tumor Suppressor Proteins