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Vesiculopustular eruptions in Down syndrome neonates with myeloproliferative disorders. Arch Dermatol 2001 Jun;137(6):760-3 PMID: 11405767

Pubmed ID



BACKGROUND: Infants with Down syndrome are at increased risk for hematologic abnormalities, including leukemoid reaction, transient myeloproliferative disorder, and congenital leukemia. The differential diagnosis of a vesiculopustular eruption in an infant with Down syndrome and these hematologic abnormalities is broad and includes benign, self-limited disorders as well as life-threatening infections.

OBSERVATION: We describe 3 newborns with Down syndrome and vesiculopustular eruptions associated with myeloproliferative disorders during the neonatal period. These lesions differ from other neonatal vesicular eruptions in that they have a unique distribution, display pathergy, and contain immature hematopoietic cells similar to circulating blast cells. Resolution occurs without treatment as the hematologic disorder subsides.

CONCLUSIONS: Infants with Down syndrome and hematologic abnormalities may have a cutaneous eruption that has characteristic clinical and histopathologic findings. It is possible that this eruption has been unrecognized in the past because of its self-limited course. Whether this eruption is a prognostic factor for the subsequent development of leukemia is uncertain.

Author List

Nijhawan A, Baselga E, Gonzalez-Ensenat MA, Vicente A, Southern JF, Camitta BM, Esterly NB, Drolet BA


Bruce M. Camitta MD Clinical Professor in the Medicine department at Medical College of Wisconsin
Beth A. Drolet MD Professor in the Dermatology department at Medical College of Wisconsin
James F. Southern MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin


2-s2.0-0034972222   26 Citations

MESH terms used to index this publication - Major topics in bold

Diagnosis, Differential
Down Syndrome
Facial Dermatoses
Fatal Outcome
Infant, Newborn
Leukemia, Myeloid, Acute
Skin Diseases, Vesiculobullous
jenkins-FCD Prod-296 4db9d02597e0a2e889e230f853b641c12f1c3ee3