Faculty Collaboration Database

Choline acetyltransferase activity parallels the pressure gradient in the feline pharyngo-esophageal region. Auton Neurosci 2001 Jun 20;89(1-2):125-7

Date

07/28/2001

Pubmed ID

11474640

DOI

10.1016/S1566-0702(01)00248-X

Scopus ID

2-s2.0-0035919229 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

Pressures generated by the pharyngeal constrictor muscles and proximal esophagus involve acetylcholine-induced muscle contractions. We hypothesized that the pharyngo-esophageal pressure gradient is related to choline acetyltransferase activity. In nine anesthetized cats, hypopharyngeal pressure and proximal esophageal pressure were recorded with a solid state transducer assembly. Enzymatic activities in the thyropharyngeus, cricopharyngeus, and proximal esophageal muscles were measured. Hypopharyngeal pressure was higher than the proximal esophagus (p < 0.01), and choline acetyltransferase activity was higher in the cricopharyngeus compared to the proximal esophagus ( p < 0.05). The pressure gradient between the hypopharynx and proximal esophagus may be influenced by the activity of choline acetyltransferase.

Author List

Xie P, Medda B, Ren J, Mustin E, Shaker R, Koch TR

Author

Reza Shaker MD Assoc Provost, Sr Assoc Dean, Ctr Dir, Chief, Prof in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acetylcholinesterase
Animals
Cats
Choline O-Acetyltransferase
Deglutition
Esophagus
Pharynx
Pressure
Vagus Nerve