Radiation therapy in the prevention of brain metastases. Curr Oncol Rep 2012 Feb;14(1):55-62
Date
12/03/2011Pubmed ID
22134834DOI
10.1007/s11912-011-0208-6Scopus ID
2-s2.0-84857638123 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Over 150,000 cancer patients will be diagnosed with brain metastases this year alone. Survival for those diagnosed with brain metastases remains poor despite multimodality management with surgery, chemotherapy, and radiation. Preventative strategies to mitigate brain metastases have met with mixed results. In leukemia and small cell lung cancer there are defined roles for preventative radiation to be delivered, which can result in improved local control and survival. There is a less defined role for preventative radiation in locally advanced non-small cell lung cancer and budding interest for radiation prevention in breast cancer. The potential impact preventative cranial irradiation may have on neurocognitive function and quality of life needs to be considered prior to its administration.
Author List
Bovi JA, White JMESH terms used to index this publication - Major topics in bold
Brain NeoplasmsBreast Neoplasms
Cognition
Cranial Irradiation
Female
Humans
Lung Neoplasms
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Quality of Life