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Serum immunoglobulin G analysis to establish a delayed diagnosis of chronic cough due to Bordetella pertussis. Otolaryngol Head Neck Surg 2012 Jan;146(1):63-7

Date

10/12/2011

Pubmed ID

21987649

Pubmed Central ID

PMC3951152

DOI

10.1177/0194599811425145

Scopus ID

2-s2.0-84857166138   9 Citations

Abstract

OBJECTIVES: Incidence of Bordetella pertussis infection among adults has risen significantly throughout the United States, but pertussis is not often considered in the differential diagnosis of chronic cough in adults. The authors hypothesized that serum IgG testing can establish a diagnosis of pertussis infection late in disease presentation when cultures and polymerase chain reaction (PCR) testing are not reliable.

STUDY DESIGN: Case series with chart review.

SETTING: Tertiary care hospital.

SUBJECTS AND METHODS: Institutional B pertussis serum IgG and PCR tests were reviewed since 2007. Clinical factors assessed included vaccination history, duration and severity of cough, and general medical history.

RESULTS: Forty-eight patients had B pertussis fimbrial agglutinogen IgG levels tested since 2007, with a significant increase in positive IgG tests (>27 IU/mL, 3 times the upper limit of normal) since fall 2009. Nineteen patients (39.5%) met IgG criteria for likely recent pertussis infection. Six IgG-positive patients also had PCR swab testing performed, with 50% positive for B pertussis. IgG values were similar for patients with positive or negative B pertussis PCR testing with positive IgG titers. IgG-positive patients were much more likely to have posttussive syncope. Recent vaccination for pertussis within the 3 years prior to IgG testing did not significantly increase IgG levels.

CONCLUSIONS: One-time B pertussis serum IgG testing and patient history can establish a likely diagnosis of recent pertussis infection in the adult patient with chronic cough late in disease presentation when PCR testing is often negative. Pertussis should be considered in the differential diagnosis of all patients with chronic cough.

Author List

Bock JM, Burtis CC, Poetker DM, Blumin JH, Frank MO

Authors

Joel H. Blumin MD Chief, Professor in the Otolaryngology department at Medical College of Wisconsin
Jonathan Bock MD Associate Professor in the Otolaryngology department at Medical College of Wisconsin
Michael O. Frank MD Vice Chair, Chief, Professor in the Medicine department at Medical College of Wisconsin
David M. Poetker MD Chief, Professor in the Otolaryngology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Antibodies, Anti-Idiotypic
Antibodies, Bacterial
Biomarkers
Bordetella pertussis
Chronic Disease
Delayed Diagnosis
Diagnosis, Differential
Female
Follow-Up Studies
Humans
Immunoglobulin G
Male
Middle Aged
Prognosis
Reproducibility of Results
Retrospective Studies
Whooping Cough
jenkins-FCD Prod-411 e00897e83867fcfa48419861683711f8d99adb75