Faculty Collaboration Database

Increase in cytochrome oxidase activity in regenerating nerve fibers of hemitransected spinal cord in the rat. Neuroreport 2001 Oct 29;12(15):3239-42

Date

11/17/2001

Pubmed ID

11711863

DOI

10.1097/00001756-200110290-00019

Scopus ID

2-s2.0-0035968878 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

We explored the possibility of cytochrome oxidase (CO) involvement in spinal cord regeneration in adult rats. The spinal cord was hemitransected at T9. After one month's survival, the animals were deeply anesthetized and perfused. The spinal cord segments including the lesion site were removed and sectioned horizontally for CO histochemistry. Under light microscope, a substantial number of CO-reactive nerve fibers and boutons were identified in the lateral funiculus adjacent to the lesion site. Under electron microscope, moderately to highly CO-reactive mitochondria could be seen within nerve fibers and boutons. Synaptic contacts were identified among them. The increase in CO activity in nerve fibers and boutons may indicate their high-energy demand for synaptic and spontaneous activity following spinal cord hemisection.

Author List

Liu YY, Wong-Riley MT, Liu HL, Jia Y, Jiao XY, Wang CT, You SW, Ju G

MESH terms used to index this publication - Major topics in bold

Animals
Biomarkers
Electron Transport Complex IV
Histocytochemistry
Microscopy, Electron
Mitochondria
Nerve Fibers
Nerve Regeneration
Presynaptic Terminals
Rats
Rats, Sprague-Dawley
Spinal Cord
Spinal Cord Injuries
Up-Regulation