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Microvascular angiogenesis and the renin-angiotensin system. Curr Hypertens Rep 2002 Feb;4(1):56-62 PMID: 11790293

Abstract

The renin-angiotensin system is one of the major regulatory mechanisms essential for maintaining cardiovascular homeostasis. Angiotensin II is a multifunctional hormone that plays a key role in regulating this system. The importance of the renin-angiotensin system in controlling sodium homeostasis and vascular resistance is well established, however, in the past decade, much attention has been focused on the importance of angiotensin II as a regulator of microvessel density, acting through the AT1 and AT2 receptors. In this review, we discuss the connections between the renin-angiotensin system and other growth factor pathways known to be involved in pathologic and physiologic angiogenesis and rarefaction.

Author List

Greene AS, Amaral SL

Author

Andrew S. Greene PhD Interim Vice Chair, Chief, Professor in the Biomedical Engineering department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Angiotensin II
Angiotensin-Converting Enzyme Inhibitors
Captopril
Endothelial Growth Factors
Heart
Homeostasis
Humans
Lymphokines
Neovascularization, Physiologic
Receptor, Angiotensin, Type 1
Receptors, Angiotensin
Renin-Angiotensin System
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors



View this publication's entry at the Pubmed website PMID: 11790293
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