Microvascular angiogenesis and the renin-angiotensin system. Curr Hypertens Rep 2002 Feb;4(1):56-62
Date
01/16/2002Pubmed ID
11790293DOI
10.1007/s11906-002-0054-xScopus ID
2-s2.0-0036483708 (requires institutional sign-in at Scopus site) 41 CitationsAbstract
The renin-angiotensin system is one of the major regulatory mechanisms essential for maintaining cardiovascular homeostasis. Angiotensin II is a multifunctional hormone that plays a key role in regulating this system. The importance of the renin-angiotensin system in controlling sodium homeostasis and vascular resistance is well established, however, in the past decade, much attention has been focused on the importance of angiotensin II as a regulator of microvessel density, acting through the AT1 and AT2 receptors. In this review, we discuss the connections between the renin-angiotensin system and other growth factor pathways known to be involved in pathologic and physiologic angiogenesis and rarefaction.
Author List
Greene AS, Amaral SLMESH terms used to index this publication - Major topics in bold
Angiotensin IIAngiotensin-Converting Enzyme Inhibitors
Captopril
Endothelial Growth Factors
Heart
Homeostasis
Humans
Lymphokines
Neovascularization, Physiologic
Receptor, Angiotensin, Type 1
Receptors, Angiotensin
Renin-Angiotensin System
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors