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HLA antigens in lichen sclerosus et atrophicus. Arch Dermatol 1990 Aug;126(8):1043-5

Date

08/01/1990

Pubmed ID

2200345

DOI

10.1001/archderm.1990.01670320067010

Scopus ID

2-s2.0-0025295889 (requires institutional sign-in at Scopus site)   43 Citations

Abstract

Several reports have found conflicting data regarding the association between lichen sclerosus et atrophicus (LSA) and HLA types. Association with HLA-A31 and -B40 has been noted, whereas another report found no correlation. We are the first to specifically examine HLA types in white patients in the United States. We have found a significant association between LSA and HLA-A29 and -B44 individually and an even stronger association with the combination of A29 and B44. A review of previous LSA-HLA studies, as well as several reports of HLA typing in familial LSA, is discussed, with consideration given to possible reasons for the discrepancies among the various studies.

Author List

Purcell KG, Spencer LV, Simpson PM, Helman SW, Oldfather JW, Fowler JF Jr

Author

Pippa M. Simpson PhD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Aged, 80 and over
Atrophy
Child
Child, Preschool
Female
HLA Antigens
HLA-A Antigens
HLA-B Antigens
HLA-B40 Antigen
HLA-B44 Antigen
Humans
Male
Middle Aged
Sclerosis
Skin Diseases