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Effects of spontaneous swallows on breathing in awake goats. J Appl Physiol (1985) 2002 May;92(5):1923-35

Date

04/19/2002

Pubmed ID

11960942

DOI

10.1152/japplphysiol.01079.2000

Scopus ID

2-s2.0-0036085666   34 Citations

Abstract

The effects of spontaneous swallows on breathing before, during, and after solitary swallows were investigated in 13 awake goats. Inspiratory (TI) and expiratory (TE) time and respiratory output were determined from inspiratory airflow [tidal volume (VT)] and peak diaphragmatic activity (Dia(peak)). The onset time for 1,128 swallows was determined from pharyngeal muscle electrical activity. During inspiration, the later the swallowing onset, the greater increase in TI and VT, whereas there was no significant effect on TE and Dia(peak). Swallows in early expiration increased the preceding TI and reduced TE, whereas later in expiration swallows increased TE. After expiratory swallows, TI and VT were reduced whereas minimal changes in Dia(peak) were observed. Phase response analysis revealed a within-breath, phase-dependent effect of swallowing on breathing, resulting in a resetting of the respiratory oscillator. However, the shift in timing in the breaths after a swallow was not parallel, further demonstrating a respiratory phase-dependent effect on breathing. We conclude that, in the awake state, within- and multiple-breath effects on respiratory timing and output are induced and/or required in the coordination of breathing and swallowing.

Author List

Feroah TR, Forster HV, Fuentes CG, Lang IM, Beste D, Martino P, Pan L, Rice T

Author

Ivan M. Lang DVM, PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Biological Clocks
Deglutition
Diaphragm
Electrodes, Implanted
Electromyography
Goats
Pharyngeal Muscles
Regression Analysis
Respiration
Time Factors
Tracheostomy
Wakefulness
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