Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis. Mol Carcinog 2013 Sep;52(9):686-91 PMID: 22456940

Pubmed ID

22456940

DOI

10.1002/mc.21907

Abstract

Betanin, also called beetroot red, has been extensively used as a food colorant. In this study, the chemopreventive activity of betanin by oral consumption was investigated in two mouse lung tumor models. Vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) were used to induce lung tumors, and female A/J mice were treated with betanin in drinking water. Betanin significantly decreased tumor multiplicity and tumor load induced by both carcinogens. Tumor multiplicity and tumor load were decreased by 20% and 39% in the VC lung model, and by 46% and 65% in the B(a)P lung model, respectively. Betanin reduced the number of CD31+ endothelial microvessels and increased the expression of caspase-3, suggesting that the lung tumor inhibitory effects were through induction of apoptosis and inhibition of angiogenesis. Betanin also induced apoptosis through activated caspase-3, -7, -9, and PARP in human lung cancer cell lines. Our data show that betanin significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a chemopreventive agent for human lung cancer.

Author List

Zhang Q, Pan J, Wang Y, Lubet R, You M

Authors

Jing Pan PhD Assistant Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin
Yian Wang MD, PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin
Ming You MD, PhD Associate Provost, Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin
Qi Zhang PhD Assistant Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




Scopus

2-s2.0-84881612712   15 Citations

MESH terms used to index this publication - Major topics in bold

Animals
Anticarcinogenic Agents
Apoptosis
Benzo(a)pyrene
Betacyanins
Caspases
Cell Transformation, Neoplastic
Endothelium, Vascular
Female
Lung Neoplasms
Mice
Mice, Inbred A
Neovascularization, Pathologic
Platelet Endothelial Cell Adhesion Molecule-1
Poly(ADP-ribose) Polymerases
Random Allocation
Urethane
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e