Cognitive and psychosocial functioning of pediatric hematopoietic stem cell transplant patients: a prospective longitudinal study. Bone Marrow Transplant 2002 Nov;30(9):609-17
Date
10/31/2002Pubmed ID
12407436DOI
10.1038/sj.bmt.1703683Scopus ID
2-s2.0-0036857638 (requires institutional sign-in at Scopus site) 65 CitationsAbstract
A prospective longitudinal study of cognitive and psychosocial functioning in pediatric hematopoietic stem cell transplant (HSCT) patients was conducted on three occasions: pre-HSCT, 1 year post-HSCT, and 2 years post-HSCT. In contrast to the previous hypothesis that cognitive declines would occur as a result of HSCT treatment, it was hypothesized that (1) global cognitive functioning (IQ scores), as well as specific areas would remain stable over time; (2) pre-transplant functioning would be predictive of later functioning; and (3) age would be negatively related to cognitive functioning. Based on previous research it was further hypothesized: that (4) while declines in psychosocial functioning might be seen at 1 year, functioning would improve by 2 years. 153 children and adolescents were evaluated pre-HSCT and at 1 year, with 2 year data available for 74 children. Longitudinal analyses of Wechsler IQ data were completed on 100 children (longitudinal exact test) and 52 children (repeated measures analysis of variance. Results of cognitive assessment indicated (1) stability of IQ scores over time; and (2) that the strongest predictor was pre-HSCT cognitive functioning. Psychosocial assessment results indicated: (1) a low prevalence of behavioral and social problems; (2) stability in functioning over time; (3) pre-HSCT functioning strongly predictive of later functioning.
Author List
Kupst MJ, Penati B, Debban B, Camitta B, Pietryga D, Margolis D, Murray K, Casper JAuthor
David A. Margolis MD Chair, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentChild
Child, Preschool
Cognition
Female
Hematologic Diseases
Hematopoietic Stem Cell Transplantation
Humans
Intelligence Tests
Longitudinal Studies
Male
Neoplasms
Predictive Value of Tests
Prognosis
Prospective Studies
Psychological Tests
Psychology
Regression Analysis
Social Behavior