Evaluation of 70/30 D,L-PLa for use as a resorbable interbody fusion cage. Orthopedics 2002 Oct;25(10 Suppl):s1131-40
Date
10/29/2002Pubmed ID
12401023DOI
10.3928/0147-7447-20021002-03Scopus ID
2-s2.0-0036804991 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
Titanium lumbar interbody spinal fusion devices are reported to be 90% effective for single-level lumbar interbody fusion, although radiographic determination of fusion has been debated. Using blinded radiographic, biomechanic, histologic, and statistical measures, researchers in the present study evaluated a radiolucent 70/30 poly(L-lactide-co-D,L-lactide) (70/30 D,L-PLa) interbody fusion device packed with autograft or rhBMP-2 on a collagen sponge in 25 sheep at 3, 6, 12, 18, and 24 months. A trend of increased fusion stiffness, radiographic fusion, and histologic fusion was demonstrated from 3 months to 24 months. Device degradation was associated with a mild to moderate chronic inflammatory response at all postoperative sacrifice times.
Author List
Toth JM, Wang M, Scifert JL, Cornwall GB, Estes BT, Seim HB 3rd, Turner ASAuthors
Jeffrey M. Toth PhD Associate Dean for Research in the School of Dentistry department at Marquette UniversityMei Wang PhD Associate Professor in the Orthopaedic Surgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Absorbable ImplantsAnimals
Biomechanical Phenomena
Bone Transplantation
Combined Modality Therapy
Disease Models, Animal
Intervertebral Disc Displacement
Lumbar Vertebrae
Osseointegration
Polyesters
Probability
Prosthesis Design
Radiography
Reference Values
Sensitivity and Specificity
Sheep
Spinal Fusion
Survival Rate
Tensile Strength
Transplantation, Autologous