Chorioamnionitis and brain injury. Clin Perinatol 2002 Dec;29(4):603-21
Date
01/09/2003Pubmed ID
12516738DOI
10.1016/s0095-5108(02)00058-1Scopus ID
2-s2.0-0036950163 (requires institutional sign-in at Scopus site) 91 CitationsAbstract
The limited available evidence supports a strong association of chorioamnionitis with neonatal encephalopathy and CP in the term infant. The association of chorioamnionitis with depressed Apgar scores or neonatal seizures and with CP is equivocal in the preterm infant. Different study results may be related to differences in study populations, perhaps specifically to differences in susceptibility by stages of neurologic development as well as differences in gene frequencies associated with inflammation and thrombophilia. We require further understanding of the normal roles of cytokines in brain development, pregnancy, and inflammatory homeostasis before clinical interventions directed at cytokines, their receptors, or the inflammatory process are considered.
Author List
Willoughby RE Jr, Nelson KBAuthor
Rodney E. Willoughby MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Anti-Bacterial AgentsBirth Injuries
Brain Injuries
Cerebral Palsy
Chorioamnionitis
Female
Genetic Predisposition to Disease
Humans
Hypoxia-Ischemia, Brain
Infant, Newborn
Infant, Premature, Diseases
Inflammation
Mass Screening
Pregnancy
Risk Factors
Sensitivity and Specificity