Transfusion therapy in postpartum hemorrhage. Semin Perinatol 2009 Apr;33(2):124-7
Date
03/28/2009Pubmed ID
19324242DOI
10.1053/j.semperi.2009.01.002Scopus ID
2-s2.0-62749126711 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
Postpartum hemorrhage (PPH) is an obstetric emergency that can occur following vaginal or cesarean delivery. Rapid diagnosis of PPH using laboratory and clinical parameters is an important first step in its management. Traditional blood components, including packed red blood cells, platelets, plasma, and cryoprecipitate, should be used in patients with significant bleeding. Recent studies underline the utility of transfusing these components in defined ratios to prevent dilutional coagulopathy. Disseminated intravascular coagulation (DIC) should be considered in severely bleeding obstetric patients and should be treated aggressively using blood components. Newer hemostatic agents, such as activated factor VII, will play significant roles in patients with bleeding that is refractory to standard therapy. Implementation of an obstetric bleeding protocol that integrates new knowledge in coagulation should aid physicians in improving outcomes for the mother and her fetus.
Author List
Padmanabhan A, Schwartz J, Spitalnik SLMESH terms used to index this publication - Major topics in bold
Blood Coagulation FactorsBlood Component Transfusion
Disseminated Intravascular Coagulation
Factor VIIa
Female
Humans
Postpartum Hemorrhage
Pregnancy
Recombinant Proteins