Free radical-mediated activation of hydrazine derivatives. Environ Health Perspect 1985 Dec;64:179-84
Date
12/01/1985Pubmed ID
3007088Pubmed Central ID
PMC1568606DOI
10.1289/ehp.8564179Scopus ID
2-s2.0-0022272164 (requires institutional sign-in at Scopus site) 50 CitationsAbstract
Hydrazines are known to undergo oxidative activation in several enzymatic systems in vitro. Free radicals or carbonium ions have been proposed as active intermediates during such activation. The toxic effects elicited by hydrazines have also been linked to free radical-mediated activation. In this report, we have reviewed the identification of organic free radicals from hydrazines by direct ESR and ESR-spin trapping.
Author List
Kalyanaraman B, Sinha BKAuthor
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsArachidonic Acid
Arachidonic Acids
Biotransformation
Cytochrome P-450 Enzyme System
Electron Spin Resonance Spectroscopy
Erythrocytes
Free Radicals
Hemoglobins
Hemolysis
Horseradish Peroxidase
Humans
Hydrazines
Oxidation-Reduction
Phenylhydrazines
Prostaglandin-Endoperoxide Synthases