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Identification by electron spin resonance spectroscopy of free radicals produced during autoxidative melanogenesis. Biochim Biophys Acta 1984 Aug 21;800(3):269-76

Date

08/21/1984

Pubmed ID

6087915

DOI

10.1016/0304-4165(84)90405-7

Scopus ID

2-s2.0-0021144551 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

Free radicals produced during the autoxidation of 3,4-dihydroxyphenylalanine (DOPA) and other catechol(amine)s to melanins have been studied using electron spin resonance spectroscopy. Magnetic parameters for the radical intermediates have been determined, allowing the radicals to be unambiguously identified. Three types of radical are formed: the primary radical from one-electron oxidation of the parent catechol(amine); and two secondary radicals, one formed via OH- substitution, the other via cyclization. The formation of these radical species can be linked to molecular products formed during catecholamine oxidation and melanin formation.

Author List

Sealy RC, Puzyna W, Kalyanaraman B, Felix CC

Author

Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Catecholamines
Dihydroxyphenylalanine
Electron Spin Resonance Spectroscopy
Free Radicals
Melanins
Oxidation-Reduction