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Chronic sinonasal disease in patients with inflammatory bowel disease. Am J Rhinol 2003 Mar-Apr;17(2):87-90



Pubmed ID




Scopus ID

2-s2.0-0038107093   24 Citations


BACKGROUND: The objective of this study was to explore the possible relationship between inflammatory bowel disease (IBD) and chronic sinonasal disease.

METHODS: A cross-sectional study was undertaken of 241 patients with Crohn's disease (CD) or ulcerative colitis from a tertiary medical center IBD clinic. Patient demographic data and information regarding IBD diagnosis and management, sinonasal disease diagnosis and management, and complications related to these diagnoses were gathered by retrospective chart review and a standardized patient survey.

RESULTS: One hundred sixty surveys (67%) were returned and analyzed. Overall 48% of patients with IBD reported chronic sinonasal disease symptoms. Patients with CD had a higher prevalence of sinonasal disease than patients with ulcerative colitis (53% versus 32%; p < 0.02). The subgroup of CD patients with obstructive bowel complications had the highest prevalence of sinonasal disease (68% versus 27%; p = < 0.001), with 23% reporting chronic rhinosinusitis, 13% reporting chronic rhinitis, and an additional 32% reporting chronic nasal or sinus symptoms.

CONCLUSION: The prevalence of chronic sinonasal disease is elevated in patients with IBD, occurring in approximately one-half of patients followed at a tertiary IBD center. Patients with CD experiencing obstructive complications had significantly increased rates of sinonasal disease. The relationship between chronic sinonasal disease and obstructive CD is not defined, but several hypotheses are generated.

Author List

Book DT, Smith TL, McNamar JP, Saeian K, Binion DG, Toohill RJ


Kia Saeian MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adrenal Cortex Hormones
Anti-Inflammatory Agents, Non-Steroidal
Chronic Disease
Cross-Sectional Studies
Data Collection
Immunosuppressive Agents
Inflammatory Bowel Diseases
Middle Aged
Paranasal Sinuses
Rhinitis, Allergic, Perennial
Statistics as Topic
Treatment Outcome
jenkins-FCD Prod-467 7c8a156729bba74d775d9c546792cde315827259