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Superoxide dismutase and catalase: a possible role in established pancreatitis. Am J Surg 1986 Jan;151(1):163-9 PMID: 2418699

Pubmed ID

2418699

Abstract

The mechanism of cerulein-induced acute pancreatitis may involve the production of free radicals in excess of the capacity of endogenous intracellular scavengers. These radicals destroy the cellular membranes, releasing digestive enzymes and cellular proteins into the interstitium. Thereafter, a cascade of events, including polymorphonuclear infiltration and complement activation, leads to pancreatic destruction. The present study demonstrates that superoxide dismutase and catalase reduce the ultrastructural and biochemical injury associated with cerulein-induced acute pancreatitis in rats. Pretreatment with superoxide dismutase and catalase 30 minutes before injury did not appear to be protective, presumably because the half-life of intravenous superoxide dismutase is only 6 minutes. This and similar studies suggest a potential clinical role for free radical scavengers in acute established pancreatitis.

Author List

Guice KS, Miller DE, Oldham KT, Townsend CM Jr, Thompson JC

Author

Keith T. Oldham MD Professor in the Surgery department at Medical College of Wisconsin




Scopus

2-s2.0-0022608170   112 Citations

MESH terms used to index this publication - Major topics in bold

Acute Disease
Animals
Catalase
Ceruletide
DNA
Disease Models, Animal
Free Radicals
Humans
In Vitro Techniques
Male
Pancreas
Pancreatitis
RNA
Rats
Rats, Inbred Strains
Superoxide Dismutase
jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad