Spatial and temporal pattern of Wnt-6 expression during chick development. Anat Embryol (Berl) 2003 May;206(6):447-51
Date
04/16/2003Pubmed ID
12695910DOI
10.1007/s00429-003-0322-9Scopus ID
2-s2.0-0038281152 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
The WNT family of proteins is composed of several members. In the present study we isolated the full length chick Wnt-6 cDNA and analyzed its expression pattern by in situ hybridization during chick development. Wnt-6 expression is observed in the ectoderm from HH-stage 4 onwards. At HH-stages, 7-16 expression can be seen in the ectoderm overlying the segmental plate and the epithelial somite, while the ectoderm overlying the compartmentalized somite is Wnt-6 negative. Expression is also observed at the heart outflow tract and in the ectoderm overlying the pharyngeal arches. From HH-stages 17 to 27, expression is also observed at limb level, both in the dorsal and ventral ectoderm and a stronger expression in the dorsoventral boundary. Furthermore, expression in the ectoderm delimiting the somitic boundaries in the anteroposterior and mediolateral axis at limb level was observed, as well as in the ventral body wall. Expression becomes evident in the inner ear. From HH-stage 30 onwards, expression is restricted to the feather buds and to the gastrointestinal tract.
Author List
Rodríguez-Niedenführ M, Dathe V, Jacob HJ, Pröls F, Christ BMESH terms used to index this publication - Major topics in bold
Amino Acid SequenceAnimals
Chick Embryo
Ectoderm
Feathers
Gene Expression Regulation, Developmental
In Situ Hybridization
Molecular Sequence Data
Proto-Oncogene Proteins
Somites
