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Cutaneous and disseminated blastomycosis: a pediatric case series. Pediatr Dermatol 2013 Jan-Feb;30(1):23-8 PMID: 23017132

Pubmed ID

23017132

Abstract

Blastomycosis is a rare fungal infection that most often initially infects the lungs and can progress to disseminated involvement of the skin, bones, and central nervous system (CNS). Pediatric blastomycosis constitutes a small portion of total cases, but delay in diagnosis may result in significant morbidity. Seventeen pediatric cases of blastomycosis were identified at Children's Hospital of Wisconsin from 1999 to 2009 through retrospective chart review; 53% had evidence of dissemination (bone, skin, or CNS) confirmed by culture. Six cases presented with cutaneous lesions, and five of these were found to have other systemic involvement. These five nonimmunosuppressed cases of primary pulmonary disease with cutaneous involvement plus dissemination to bone or the CNS are reported in detail. The diagnosis of blastomycosis in children is often delayed, and dissemination by the time of diagnosis may be more common than in adults. Cutaneous dissemination may occur in immunocompetent children, may indicate underlying systemic involvement, and can be more readily identified than symptoms of bony or neurologic involvement. These reported cases indicate the importance of dermatologists recognizing and investigating all potentially involved organ systems when a patient presents with characteristic skin lesions with or without a history of respiratory illness.

Author List

Brick KE, Drolet BA, Lyon VB, Galbraith SS

Author

Beth A. Drolet MD Professor in the Dermatology department at Medical College of Wisconsin




Scopus

2-s2.0-84872320581   12 Citations

MESH terms used to index this publication - Major topics in bold

Adolescent
Age Distribution
Antifungal Agents
Blastomyces
Blastomycosis
Child
Child, Preschool
Cohort Studies
Dermatomycoses
Female
Follow-Up Studies
Fungemia
Hospitals, Pediatric
Humans
Incidence
Male
Retrospective Studies
Risk Assessment
Severity of Illness Index
Sex Distribution
Treatment Outcome
Wisconsin
jenkins-FCD Prod-296 4db9d02597e0a2e889e230f853b641c12f1c3ee3