Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy. Epilepsy Behav 2012 Jan;23(1):64-7
Date
11/22/2011Pubmed ID
22099527Pubmed Central ID
PMC3259282DOI
10.1016/j.yebeh.2011.10.001Scopus ID
2-s2.0-84855907183 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
Depression in patients with temporal lobe epilepsy (TLE) is highly prevalent and carries significant morbidity and mortality. Its neural basis is poorly understood. We used quantitative, surface-based MRI analysis to correlate brain morphometry with severity of depressive symptoms in 38 patients with TLE and 45 controls. Increasing severity of depressive symptoms was associated with orbitofrontal cortex (OFC) thinning in controls, but with OFC thickening in TLE patients. These results demonstrate distinct neuroanatomical substrates for depression with and without TLE, and suggest a unique role for OFC, a limbic region for emotional processing strongly interconnected with medial temporal structures, in TLE-related depressive symptoms.
Author List
Butler T, Blackmon K, McDonald CR, Carlson C, Barr WB, Devinsky O, Kuzniecky R, DuBois J, French J, Halgren E, Thesen TAuthor
Chad Carlson MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultCerebral Cortex
Depression
Electroencephalography
Epilepsy, Temporal Lobe
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Psychiatric Status Rating Scales