Cranberry proanthocyanidins mediate growth arrest of lung cancer cells through modulation of gene expression and rapid induction of apoptosis. Molecules 2011 Mar 11;16(3):2375-90
Date
03/15/2011Pubmed ID
21399574Pubmed Central ID
PMC6259838DOI
10.3390/molecules16032375Scopus ID
2-s2.0-79953137610 (requires institutional sign-in at Scopus site) 40 CitationsAbstract
Cranberries are rich in bioactive constituents purported to enhance immune function, improve urinary tract health, reduce cardiovascular disease and more recently, inhibit cancer in preclinical models. However, identification of the cranberry constituents with the strongest cancer inhibitory potential and the mechanism associated with cancer inhibition by cranberries remains to be elucidated. This study investigated the ability of a proanthocyanidin rich cranberry fraction (PAC) to alter gene expression, induce apoptosis and impact the cell cycle machinery of human NCI-H460 lung cancer cells. Lung cancer is the leading cause of cancer-related deaths in the United States and five year survival rates remain poor at 16%. Thus, assessing potential inhibitors of lung cancer-linked signaling pathways is an active area of investigation.
Author List
Kresty LA, Howell AB, Baird MMESH terms used to index this publication - Major topics in bold
ApoptosisCell Division
Cell Line, Tumor
Flow Cytometry
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms
Polymerase Chain Reaction
Proanthocyanidins
Vaccinium macrocarpon