Mitochondrial myopathy: a rare cause of early-onset vocal fold atrophy. Ann Otol Rhinol Laryngol 2013 Mar;122(3):177-82
Date
04/13/2013Pubmed ID
23577570Pubmed Central ID
PMC3951151DOI
10.1177/000348941312200306Scopus ID
2-s2.0-84874832544 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
OBJECTIVES: We present the second published case of laryngeal involvement in mitochondrial myopathy.
METHODS: A patient with laryngeal involvement of mitochondrial myopathy is presented, together with a literature review.
RESULTS: A 41-year-old man presented with progressive breathy dysphonia. His brother had mitochondrial myopathy. Biopsy of the biceps muscle demonstrated cytochrome C oxidase-negative ragged blue fibers confirming mitochondrial myopathy. Videostroboscopy showed marked vocal fold atrophy, but subsequent injection laryngoplasty did not significantly improve the patient's voice, despite improved postoperative glottic closure.
CONCLUSIONS: Mitochondrial myopathy should be considered in the differential diagnosis of severe early-onset vocal fold atrophy.
Author List
Kelly EA, Bock JM, Peltier AC, Oh SJ, Garrett CGAuthor
Jonathan Bock MD Professor in the Otolaryngology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAtrophy
Deglutition Disorders
Dysphonia
Humans
Laryngeal Muscles
Laryngoplasty
Male
Mitochondrial Myopathies
Vocal Cords