Medical College of Wisconsin
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Finding the maximum safe dose level for heteroscedastic data. J Biopharm Stat 2004 Nov;14(4):843-56 PMID: 15587967

Pubmed ID



In this article we extend to the heteroscedastic setting the multiple stepwise test procedures proposed in Tamhane et al. [Tamhane. A. C., Dunnett, C. W., Green, J. W., Wetherington, J. F. (2001). Multiple test procedures for identifying a safe dose. J. Am. Statist. Assoc. 96:835-843] for finding the maximum safe dose. Toxicological data are often heteroscedastic; therefore, the extensions given herein should be highly useful in practice. Simulations are performed to study the Type I familywise error rate and power properties of the procedures. A real data example is given to illustrate the procedures.

Author List

Tamhane AC, Logan BR


Brent R. Logan PhD Director, Professor in the Institute for Health and Equity department at Medical College of Wisconsin


2-s2.0-9244227065   8 Citations

MESH terms used to index this publication - Major topics in bold

Computer Simulation
Data Interpretation, Statistical
Dose-Response Relationship, Drug
Drug-Related Side Effects and Adverse Reactions
Monte Carlo Method
Pharmaceutical Preparations
jenkins-FCD Prod-332 f92a19b0ec5e8e1eff783fac390ec127e367c2b5