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The emergence of severe pulmonary hemorrhagic leptospirosis: questions to consider. Front Cell Infect Microbiol 2011;1:24 PMID: 22919589 PMCID: PMC3417368

Pubmed ID

22919589

DOI

10.3389/fcimb.2011.00024

Abstract

Since the 1980s, the incidence of severe pulmonary hemorrhage caused by Leptospira spp. infection has increased. The mild, non-specific symptoms or the more classical form of severe disease with hepatorenal manifestations, Weil's syndrome, predominate world-wide. However, several regions of the world have seen increases in numbers of patients with pulmonary hemorrhage attributed to leptospirosis. The reasons behind the emergence of this syndrome, which carries a high mortality rate, are not known. Several avenues for future research may shed light on the mechanisms involved in development of pulmonary hemorrhage, and inform targeted therapeutics to improve outcomes. Possibilities to consider include: (1) emergence of new bacterial strains, (2) acquisition of virulence traits by strains in the endemic regions, (3) changes in underlying health of the affected human populations, and (4) increased recognition of the syndrome and better record keeping by the medical and veterinary communities. Determining the causes of emerging clinical manifestations presents challenges and opportunities for potentially life-saving research into the pathogenesis of a number of infectious diseases, including leptospirosis.

Author List

Truong KN, Coburn J

Author

Jenifer Coburn PhD Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-84879538428   5 Citations

MESH terms used to index this publication - Major topics in bold

Animals
Communicable Diseases, Emerging
Hemorrhage
Humans
Leptospira
Leptospirosis
Lung Diseases
Risk Factors
Virulence
jenkins-FCD Prod-331 a335b1a6d1e9c32173c9534e6f6ff51494143916