Reductive stress on life span extension in C. elegans. BMC Res Notes 2008 Jun 04;1:19
Date
08/20/2008Pubmed ID
18710529Pubmed Central ID
PMC2518267DOI
10.1186/1756-0500-1-19Scopus ID
2-s2.0-67650936587 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Recently, Schulz and colleagues have contributed to the ongoing controversy on the unproven role of oxidative stress in the aging process in their well-performed study 'Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress' (Cell Metab 2007, 6: 280-293). Here, we suggest an alternative hypothesis that reductive stress can prevent calorie-restriction induced life span extension. We draw attention to this condition as an explanation for some contradictory observations including the deleterious effects from antioxidants.