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Asymptomatic 50% to 75% internal carotid artery stenosis in 288 patients: risk factors for disease progression and ipsilateral neurological symptoms. Perspect Vasc Surg Endovasc Ther 2012 Dec;24(4):165-70

Date

06/28/2013

Pubmed ID

23804963

DOI

10.1177/1531003513491986

Scopus ID

2-s2.0-84884585380   3 Citations

Abstract

INTRODUCTION: This study identified characteristics of patients with moderate internal carotid artery stenosis that are at increased risk for disease progression.

METHODS: Patients with asymptomatic moderate internal carotid disease correlating to 50% to 75% diameter reduction were followed for 3 years. Progression to greater than 75% diameter reduction or presentation with focal neurological symptoms was documented. Descriptive statistics and χ(2) testing provided statistical analysis.

RESULTS: During follow-up, 26 (9%) developed symptoms or had an asymptomatic increase in diameter reduction to >75%. The rate of disease progression and/or development of symptoms was 5.5% at 12 months and increased to 7.2% by 24 months. Comorbidities with the highest associated event incidences were coronary artery disease (8.1%), hyperlipidemia (7.3%), and hypertension (6.7%).

CONCLUSION: Male patients with coronary artery disease, hyperlipidemia, and hypertension are at increased risk and are candidates for frequent screening and/or early intervention.

Author List

Dua A, Patel B, Kuy S, Seabrook GR, Tondravi N, Brown KR, Lewis BD, Rossi PJ

Authors

Kellie R. Brown MD Professor in the Surgery department at Medical College of Wisconsin
Brian D. Lewis MD Professor in the Surgery department at Medical College of Wisconsin
Peter J. Rossi MD Chief, Associate Professor in the Surgery department at Medical College of Wisconsin
Gary R. Seabrook MD Chief, Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Asymptomatic Diseases
Carotid Artery, Internal
Carotid Stenosis
Cerebrovascular Disorders
Comorbidity
Coronary Artery Disease
Disease Progression
Female
Humans
Hyperlipidemias
Hypertension
Incidence
Male
Middle Aged
Retrospective Studies
Risk Factors
Severity of Illness Index
Sex Factors
Time Factors
Wisconsin
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