Psychosocial factors and hematopoietic stem cell transplantation: potential biobehavioral pathways. Psychoneuroendocrinology 2013 Nov;38(11):2383-93
Date
07/13/2013Pubmed ID
23845514Pubmed Central ID
PMC3812389DOI
10.1016/j.psyneuen.2013.06.016Scopus ID
2-s2.0-84886092543 (requires institutional sign-in at Scopus site) 38 CitationsAbstract
While psychosocial factors are known to affect cancer progression via biobehavioral pathways in many patient populations, these relationships remain largely unexplored in hematopoietic stem cell transplant (HCT) patients. The purpose of this paper is to critically review the literature regarding psychosocial and endocrine/immune aspects of HCT, with an emphasis on exploring pathways that may mediate the associations between psychosocial factors and disease outcomes. These include the roles of catecholamines, glucocorticoids, inflammation, vascular endothelial growth factor (VEGF), immune reconstitution and infectious susceptibility, as well as the new opportunities available in genomics research. We also discuss the implications for potential immunomodulating psychosocial interventions. Elucidating the biological pathways that account for the associations between psychosocial factors and clinical course could ultimately lead to improved outcomes for this psychologically and immunologically vulnerable population.
Author List
Knight JM, Lyness JM, Sahler OJ, Liesveld JL, Moynihan JAAuthor
Jennifer M. Knight MD, MS Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
GenomicsHematopoietic Stem Cell Transplantation
Humans
Immunomodulation
Neoplasms
Treatment Outcome