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Illuminating the roles of the Borrelia burgdorferi adhesins. Trends Microbiol 2013 Aug;21(8):372-9 PMID: 23876218 PMCID: PMC3773214

Pubmed ID

23876218

Abstract

The Lyme disease spirochetes, Borrelia burgdorferi (sensu lato), must cause persistent, disseminated infection to be maintained in the natural enzootic cycle. In human Lyme disease, spirochetes spread from the site of a tick bite to colonize multiple tissue sites, causing multisystem clinical manifestations. The Lyme spirochetes produce many adhesive surface proteins that collectively recognize diverse host substrates and cell types and are likely to promote dissemination and chronic infection in a variety of tissues. Recent application of state-of-the-art in vivo imaging technologies is illuminating mechanisms of interaction of B. burgdorferi with the host and the importance of multiple adhesins during mammalian infection.

Author List

Coburn J, Leong J, Chaconas G

Author

Jenifer Coburn PhD Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-84881028121   43 Citations

MESH terms used to index this publication - Major topics in bold

Adhesins, Bacterial
Animals
Bacterial Adhesion
Borrelia burgdorferi Group
Host-Pathogen Interactions
Humans
Microscopy
Optical Imaging
jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6