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Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol 2012 Nov;12(11):749-61

Date

10/20/2012

Pubmed ID

23080391

Pubmed Central ID

PMC4137483

DOI

10.1038/nri3307

Scopus ID

2-s2.0-84867896903   570 Citations

Abstract

During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8(+) T cells have started to be characterized, and this Review discusses the major advances in these areas.

Author List

Kaech SM, Cui W

Author

Weiguo Cui PhD Associate Professor in the Microbiology and Immunology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
CD8-Positive T-Lymphocytes
Cell Differentiation
Gene Expression Regulation
Humans
Immunologic Memory
Infection
Lymphocyte Activation
Signal Transduction
Transcription, Genetic
jenkins-FCD Prod-400 0f9a74600e4e79798f8fa6f545ea115f3dd948b2