Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol 2012 Nov;12(11):749-61
Date
10/20/2012Pubmed ID
23080391Pubmed Central ID
PMC4137483DOI
10.1038/nri3307Scopus ID
2-s2.0-84867896903 (requires institutional sign-in at Scopus site) 1074 CitationsAbstract
During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8(+) T cells have started to be characterized, and this Review discusses the major advances in these areas.
Author List
Kaech SM, Cui WMESH terms used to index this publication - Major topics in bold
AnimalsCD8-Positive T-Lymphocytes
Cell Differentiation
Gene Expression Regulation
Humans
Immunologic Memory
Lymphocyte Activation
Signal Transduction
Transcription, Genetic
