Faculty Collaboration Database

Contributions of the Kölliker-Fuse nucleus to coordination of breathing and swallowing. Respir Physiol Neurobiol 2013 Oct 01;189(1):10-21

Date

06/19/2013

Pubmed ID

23774145

Pubmed Central ID

PMC4338573

DOI

10.1016/j.resp.2013.06.003

Scopus ID

2-s2.0-84881235978 (requires institutional sign-in at Scopus site)   20 Citations

Abstract

Herein we compare the effects of perturbations in the Kölliker-Fuse nucleus (KFN) and the lateral (LPBN) and medial (MPBN) parabrachial nuclei on the coordination of breathing and swallowing. Cannula was chronically implanted in goats through which ibotenic acid (IA) was injected while awake. Swallows in late expiration (E) always reset while swallows in early inspiration (I) never reset the respiratory rhythm. Before cannula implantation, all other E and I swallows did not reset the respiratory rhythm, and had small effects on E and I duration and tidal volume (VT). However, after cannula implantation in the MPBN and KFN, E and I swallows reset the respiratory rhythm and increased the effects on I and E duration and VT. Subsequent injection of IA into the KFN eliminated the respiratory phase resetting of swallows but exacerbated the effects on I and E duration and VT. We conclude that the KFN and to a lesser extent the MPBN contribute to coordination of breathing and swallowing.

Author List

Bonis JM, Neumueller SE, Krause KL, Pan LG, Hodges MR, Forster HV

Authors

Hubert V. Forster PhD Professor in the Physiology department at Medical College of Wisconsin
Matthew R. Hodges PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Deglutition
Goats
Pons
Respiration
Respiratory Physiological Phenomena