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Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia. Paediatr Anaesth 2004 Oct;14(10):831-7

Date

09/24/2004

Pubmed ID

15385011

DOI

10.1111/j.1460-9592.2004.01472.x

Scopus ID

2-s2.0-4944220495   12 Citations

Abstract

BACKGROUND: Droperidol is useful for postoperative sedation in infants and children after cardiac surgery because it provides sedation and akinesia with minimal respiratory depression. However, droperidol has been associated with QT prolongation and ventricular arrhythmias. We investigated, if neuroleptanalgesic doses of droperidol led to QT prolongation and cardiac arrhythmias in children undergoing cardiac surgery.

METHODS: We retrospectively analysed electrocardiogram rhythm strips that were obtained before and in time increments after a 100 microg x kg(-1) intravenous bolus of droperidol in 20 children undergoing cardiac surgery. The longest QT interval was determined in each ECG and corrected for heart rate (QTc). All arrhythmias were recorded.

RESULTS: Droperidol led to a significant increase in QTc time that was still present at 15 min but had resolved within 30 min after the bolus. No associated arrhythmias were observed.

CONCLUSIONS: The statistically significant prolongation of QTc time after a sedative dose of droperidol is of concern because it may increase the risk for malignant cardiac arrhythmias. A large, prospective study is necessary to identify the true risk for arrhythmias after droperidol in this patient population, but our study suggests that any arrhythmogenic risk, if present, will be very transient, since the increase in QTc time was limited to a period of less than 30 min after the bolus.

Author List

Stuth EA, Stucke AG, Cava JR, Hoffman GM, Berens RJ

Authors

Richard J. Berens MD Professor in the Anesthesiology department at Medical College of Wisconsin
Joseph R. Cava MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin
George M. Hoffman MD Chief, Professor in the Anesthesiology department at Medical College of Wisconsin
Astrid G. Stucke MD Associate Professor in the Anesthesiology department at Medical College of Wisconsin
Eckehard A. Stuth MD Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adjuvants, Anesthesia
Anesthesia, Inhalation
Arrhythmias, Cardiac
Cardiac Surgical Procedures
Droperidol
Electrocardiography
Female
Humans
Infant
Long QT Syndrome
Male
Neuroleptanalgesia
Retrospective Studies
jenkins-FCD Prod-411 e00897e83867fcfa48419861683711f8d99adb75